Absalom B. Moore was born on May 16, 1815, in Spotsylvania, Virginia, the son of Elizibeth "Betsy" and John Moore. His parents later moved their family to Owen County, Kentucky. He married Jane McWest Lineback on October 6, 1839, in New Liberty, Owen County, Kentucky. They had seven children in 16 years.
After Jane's death in 1867, Absalom remarried and moved with his new wife, Rebecca, and children Atha, Susie, and Robert to Vevay, Indiana.
In 1877, Absalom traveled west to Pueblo, Colorado and spent five months exploring the Colorado Mountains. He then traveled across Colorado into Kansas and traveled through Dodge City and Ashland before returning east to Indiana.
In Vevay he worked as a tailor and opened a shop on Main Street. He later moved back to Kentucky and lived with his daughter, Atha, and her husband and family in Warsaw until Atha's death in 1881. He shared the stories of his travels out west that influenced his daughter Susie and her husband William Lindley, along with his son Robert and other family and friends to leave Vevay and move to the West to homestead. They left Vevay in a Wagon Train west to Colorado sometime in the spring of 1883. He later moved to Mason County Illinois to live with his daughter Mary Helen Moore Brisby/Vannaken. He died on January 17, 1887, in Mason County, Illinois, and is buried in the New Lebanon Cemetery in Kilbourne, Mason County, Illinois.