| Year | Ailment | Place | Other info |
|---|---|---|---|
| 1350 | Bubonic plague | WW | * |
| 1499 | Bubonic plague | UK London | - |
| 1507 | "Fever" | UK | * 1507-51 |
| 1551 | Influenza | UK | - |
| 1555 | Famine | UK | Rains brought famine & weakness |
| 1556 | Bubonic plague | UK | * 1556-63 Extreme |
| 1578 | Bubonic plague | UK | - |
| 1586 | Bubonic plague | UK | * Chesterfield. Harvest failed |
| 1591 | Acute distress | UK | - |
| 1593 | Bubonic plague | UK | - |
| 1596 | Famine | UK | * Harvests failed & epidemics |
| 1603 | Bubonic plague | UK | - |
| 1612 | Bubonic plague | UK | - |
| 1617 | Smallpox | US | * Native Americans |
| 1623 | Bad years | UK | * 2 years |
| 1625 | Bubonic plague | UK | - |
| 1626 | Bubonic plague | UK | - |
| 1630 | Very bad year | UK | Many died |
| 1631 | Bubonic plague | UK | - |
| 1633 | Smallpox | US | * Native Americans |
| 1636 | Bubonic plague | UK | - |
| 1637 | Bubonic plague | UK | - |
| 1647 | Yellow Fever | West Indies | - |
| 1648 | Smallpox | US | - |
| 1648 | Whooping cough | US | - |
| 1654 | Bubonic plague | UK | - |
| 1657 | Measles | US-Boston | - |
| 1662 | Smallpox | US-NY | - |
| 1665 | Bubonic plague | UK | * Extreme |
| 1668 | Yellow Fever | US-NY | - |
| 1677 | Smallpox | US-Boston | * |
| 1687 | Measles | US-Boston | - |
| 1690 | Yellow Fever | US-NY | - |
| 1699 | Yellow Fever | US-SC | - |
| 1702 | Yellow Fever | US-NY | * |
| 1702 | Scarlet Fever | US-Boston | - |
| 1706 | Yellow Fever | US-SC | - |
| 1713 | Measles | US-Boston | - |
| 1721 | Smallpox | US-Boston | - |
| 1723 | Influenza | WW | - |
| 1723 | Famine | UK | * 7 years poor harvests & epidemics |
| 1728 | Yellow Fever | US-SC | - |
| 1729 | Measles | US-Boston | - |
| 1732 | Yellow Fever | US-SC | - |
| 1732 | Influenza | WW | * |
| 1735 | Diphtheria/scarlet fever | US | * 4 yrs - New England |
| 1738 | Smallpox | US-SC | - |
| 1739 | Measles | US-Boston | * |
| 1743 | Yellow Fever | US-NY | * |
| 1747 | Measles | US-CT, NY, PA, SC | - |
| 1759 | Measles | North America | - |
| 1761 | Influenza | US & West Indies | - |
| 1763 | Smallpox | US-Boston | * |
| 1772 | Measles | US | - |
| 1775 | Influenza | WW | * |
| 1783 | Bilious disorder | US | Fatal |
| 1788 | Measles | US-PA, NY | - |
| 1789 | Influenza | US | - |
| 1792 | Yellow Fever | US | * 7 yrs |
| 1793 | Unknown | US-PA | - |
| 1793 | Influenza | US-VT, VA | - |
| 1802 | Smallpox | US-NE | - |
| 1803 | Yellow Fever | US-NY | - |
| 1820 | "Fever" | US | * |
| 1826 | Cholera | WW | * 1826-37 |
| 1826 | Dengue Fever | US and West Indies | * |
| 1829 | Malaria | US | * |
| 1831 | Cholera | UK, US-OH, NY | * Started WW 1826 |
| 1832 | Influenza | US | - |
| 1837 | Typhus | US-PA | - |
| 1837 | Smallpox | US-Native Americans | - |
| 1841 | Yellow Fever | US | - |
| 1847 | Measles | US-Native Americans | - |
| 1847 | Yellow Fever | US-New Orleans | - |
| 1847 | Influenza | WW | * |
| 1848 | Cholera | WW | * |
| 1850 | Yellow Fever | US | - |
| 1850 | Influenza | US | * |
| 1850 | Dengue Fever | US | * |
| 1851 | Cholera | US-IL | - |
| 1852 | Yellow Fever | US-New Orleans | - |
| 1853 | Cholera | Birmingham? This came from a UK report with the ? | - |
| 1855 | Yellow Fever | US | - |
| 1857 | Influenza | WW | * |
| 1860 | Smallpox | US-PA | - |
| 1861 | Numerous Epidemics | US-Civil war numerous infectious diseases | * |
| 1865 | Smallpox | US | * |
| 1865 | Cholera | US | - |
| 1865 | Typhus | US | * |
| 1868 | Smallpox | US | * 7 yrs |
| 1873 | Influenza | UK, US & Europe | * |
| 1873 | Cholera | US | - |
| 1878 | Yellow Fever | US-New Orleans | - |
| 1885 | Typhoid | US-PA | - |
| 1886 | Yellow Fever | US-FL | - |
| 1889 | Influenza | WW | * |
| 1893 | Polio | US | 1st known outbreak |
| 1900 | Plague | US | * |
| 1901 | Smallpox | US | * |
| 1907 | Polio | US | * 9 yrs. |
| 1917 | Influenza | WW | * Worst ever |
| 1931 | Polio | US | * 1931 to 1942, 11 yrs |