USS Guardfish (SS-217), a Gato-class submarine, was the first ship of the United States Navy to be named for the guardfish.

Guardfish was laid down by the Electric Boat Company at Groton, Connecticut. She was launched there on 20 January 1942 (sponsored by Mrs. Edward J. Marquart), and commissioned at New London, Conn., 8 May 1942, Lt. Comdr. Thomas B. Klakring in command. 

First and second war patrols, August – November 1942

After conducting shakedown out of New London, Guardfish departed that base 28 June 1942 for Pearl Harbor via the Panama Canal, and arrived there 25 July to prepare for her first cruise. Her first war patrol was in previously unpatrolled waters off northeast Honshū. Guardfish departed Pearl Harbor 6 August 1942, sank a trawler 22 August, and two days later sank 3,114 ton cargo ship Seikai Maru off Kinkasan Harbor. Evading escort vessels, she proceeded up the coast and found a convoy 2 September. Guardfish attacked the next day, sinking 5,253 ton Kaimei Maru and 1,118 ton cargo ship Tenyu Maru. Chita Maru, a 2,376 ton freighter, retreated into the harbor and anchored, but a long-range shot from Guardfish left her beached in the mud. Guardfish returned from her successful first patrol to Midway for refit 15 September 1942.

Guardfish departed Midway on her second war patrol 30 September and headed for the East China Sea. Surviving a violent attack by patrolling aircraft 19 October, Guardfish closed a seven-ship convoy 21 October, sinking a 4,000-ton freighter and 6,362 ton Nichiho Maru north of Formosa as the convoy scattered. After evading pursuing aircraft and surface ships, Guardfish returned to Pearl Harbor 28 November 1942. For her success' on these first two patrols, Guardfish received a Presidential Unit Citation.

Third, fourth, and fifth war patrols, January – August 1943

Moving her base of operations to the Truk area, Guardfish departed Pearl Harbor 2 January 1943 to patrol off the Japanese stronghold. She sank a Japanese patrol vessel (Patrol Boat No.1, the ex-destroyer Shimakaze) 12 January west of Kavieng, and a 1,300 ton cargo ship the next day. Attacked by destroyer Hakaze 23 January, Guardfish sank her with a well-placed torpedo. Moving south toward Rabaul, she attacked a large convoy near Simpson Harbor, but was driven off by concentrated shore fire and escort attacks. Guardfish ended her third patrol by arriving at Brisbane, Australia, 15 February 1943.

Her fourth war patrol was conducted in the Bismarcks, Solomons, and New Guinea area, and Guardfish recorded no kills during this cruise, 9 March to 30 April 1943.

Departing Brisbane for the same waters 25 May 1943, Guardfish sank 201 ton freighter Suzuya Maru and damaged another before being forced to dive by aircraft 13 June. She picked up a surveying party on the west coast of Bougainville 14 July and returned to Brisbane for refit 2 August 1943.

Sixth and seventh war patrols, August 1943 – February 1944

Guardfish departed Brisbane for her sixth war patrol 24 August 1943, landing a reconnoitering party on Bougainville and then moving into cruising waters. She sank 5,460 ton Kasha Maru 8 October and subsequently spent two days as lifeguard ship during the air strikes on Rabaul. Guardfish embarked another reconnoitering party 19 October at Tulagi, landed them on Bougainville, and took vital soundings in Empress Augusta Bay before re-embarking the Marine party 28 October. These important missions were carried out a scant two days before the American landings at Bougainville. Guardfish reached Brisbane, closing out her sixth patrol, 3 November 1943.

On 3 December 1943 Guardfish was damaged in a collision with an unknown tanker.^[7]

Turning to the shipping lanes between Truk and Guadalcanal, Guardfish began her seventh war patrol 27 December 1943, sinking 10,024 ton oiler Kenyo Maru 14 January 1944. She then closed Truk and sank destroyer Urakaze 1 February during an attack on a convoy. After serving briefly as lifeguard ship off Truk she arrived at Pearl Harbor 18 February and from there returned to San Francisco for repairs nine days later.

Eighth and ninth war patrols, June – October 1944

Guardfish again put to sea from San Francisco and arrived at Pearl Harbor 1 June. She then joined submarines Thresher, Piranha, and Apogon to form the coordinated attack group known as the "Mickey Finns", commanded by Captain W. V. O'Regan in Guardfish. The submarines patrolled the shipping lanes around Formosa with spectacular success, Guardfish sinking 5,863 ton auxiliary Mantai Maru, 2,838 ton cargo ship Hizan Maru, and 5,215 ton cargo ship Jinsan Maru southwest of Formosa 17 July. After damaging another freighter 18 July, Guardfish sank 5,872 ton Teiryu Maru the next day, barely escaping the attacks of her escort vessels. She arrived at Midway for refit 31 July 1944, and for her performance on the eighth patrol was awarded a second Presidential Unit Citation.

Sailing the Sea of Japan as a member of another wolf pack 23 August 1944, Guardfish and the submarines, Thresher and Sunfish, had a 40-minute surface gun battle with sampans 2 September. On 25 September Guardfish attacked and sank 873 ton cargo ship Miyakawa Maru #2 and returned to Pearl Harbor 24 October 1944.

Tenth, eleventh, and twelfth war patrols, November 1944 – June 1945

Guardfish departed 26 November for her 10th war patrol to cruise in the "Convoy College" area of the South China Sea, with yet another wolf pack. She recorded no sinkings during this cruise, but nearing Guam in the early morning of 24 January she mistook the American salvage ship Extractor (ARS-15), for a Japanese I class submarine. She fired a torpedo which struck Extractor's starboard side, causing her to capsize and sink at

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Guardfish's 11th war patrol was spent watching for enemy fleet units attempting to escape from the Inland Sea of Japan by way of the Kii Suido between Shikoku and Honshū. Departing Saipan on this duty 27 February, she found no ships but rescued two downed aviators on the 19 March before returning to Midway 11 April 1945.

Guardfish departed Midway 8 May 1945 on her 12th and last war patrol, and was assigned lifeguard station for the ever-increasing air attacks on the Japanese mainland. She sank a small trawler with gunfire 16 June, and arrived back at Pearl Harbor 26 June 1945.